导师团队
翁建平
文章来源:内分泌与代谢病研究所    发布时间:2022-07-09  


翁建平,1965年8月出生,二级教授,一级主任医师。


现任中国科学技术大学生命科学与医学部副部长,安徽医科大学校长,中国科学技术大学临床医学院执行院长,中科院临床研究医院(合肥)执行院长,中国科学技术大学附属第一医院副院长,中国科学技术大学内分泌与代谢病研究所所长。

系教育部长江学者特聘教授,国家杰出青年基金获得者。中华医学会理事、中国医师协会内分泌代谢科医师分会副会长、中华医学会糖尿病学分会名誉主任委员、国家放射与介入临床医学中心泛血管专业委员会副主任委员、国家心血管专家委员会心血管代谢医学专业委员会常务委员、中国老年学和老年医学学会老年病学分会副会长、中国生物物理学会表型组学分会副会长、亚洲分子糖尿病研究会副主席、广东省精准医学应用学会会长;兼任《中华糖尿病杂志》总编辑、《中国科学技术大学学报》执行副主编、Associate Editor of Chinese Medical Journal (Engl.)、Associate Editor of Journal of Diabetes、BMJ international advisory board、Co-Editor of Diabetes/Metabolism Research and Reviews、Associate Editor of Journal of Diabetes Investigation等。

 

一、学习及工作经历


学习经历

1980~1985 东南大学医学院(原南京铁道医学院)获医学学士学位

1988~1991 中山大学(原中山医科大学) 获临床医学硕士学位

1993~1996 中山大学(原中山医科大学) 获临床医学博士学位

1997~2000 瑞典隆德大学Malmo总医院 博士后

2007~2007 澳大利亚新南威尔士大学 St.Vincent’s 医院(教育部高级访问学者)

工作经历

1991∼1997 中山大学附属第一医院内分泌科 住院医师、主治医师。

1997∼2000 中山大学附属第一医院内分泌科副主任、副教授。

2000∼2007 中山大学附属第一医院内分泌科主任、教授、学科带头人。

2007∼2015 中山大学附属第三医院副院长。

2015∼2018 中山大学附属第三医院内分泌科主任、教授。

2018~2019 中国科学技术大学临床医学院执行院长、中国科学技术大学附属第一医院(安徽省立医院)副院长。

2019~2020 中国科学技术大学生命科学与医学部副部长,中国科学技术大学临床医学院执行院长,中国科学技术大学附属第一医院(安徽省立医院)副院长,中科院临床研究医院(合肥)执行院长,中国科学技术大学内分泌与代谢病研究所所长。

2020~2024.03 中国科学技术大学生命科学与医学部副部长、蚌埠医科大学校长、中国科学技术大学临床医学院执行院长、中国科学技术大学附属第一医院(安徽省立医院)副院长,中科院临床研究医院(合肥)执行院长,中国科学技术大学内分泌与代谢病研究所所长。

2024.03~至今 中国科学技术大学生命科学与医学部副部长,安徽医科大学校长,中国科学技术大学临床医学院执行院长,中国科学技术大学附属第一医院(安徽省立医院)副院长,中科院临床研究医院(合肥)执行院长,中国科学技术大学内分泌与代谢病研究所所长。

 

二、学术成果及影响


致力于医学教育、临床工作和科学研究30余年,自2003年开始招收临床医学博士研究生以来,已培养博士研究生46名。第一个证明了2型糖尿病胰岛功能可逆,提出并验证了“2型糖尿病β细胞休整”学说,制定了“2型糖尿病胰岛素早期强化治疗方案”国际共识和国内共识,作为总负责人牵头制定《中国糖尿病防治指南》2013版,牵头发布2型糖尿病诊治中国标准( Standards of care for type 2 diabetes in China 2016)。是第一个担任新药III期临床注册研究全球PI的中国临床医生(2012年,德国勃林格殷格翰公司恩格列净First-in-class)。

两次承担教育部“长江学者和创新团队发展计划”,牵头国家重点研发计划、十二五重大科技专项、国家自然基金委重点项目、面上项目和杰出青年基金项目、国家卫计委公益性行业基金项目、973课题、863课题、中科院战略性先导科技专项和卫生部部属医院临床学科重点项目等多个大型项目,以第一完成人获2011年度国家科技进步奖二等奖和2006年度教育部科技进步奖一等奖,于2018年获中华医学会糖尿病学分会(CDS)最高学术奖项-科学贡献奖,并于2022年中华医学科学技术奖二等奖。

在National Science Reviews、NEJM、Lancet、British Medical Journal、Lancet Diabetes & Endocrinology、Hepatology、Circulation、Diabetes Care、Diabetes等国际学术期刊发表SCI论文230多篇,总引用频次超过12000次,2020年、2021年、2022年和2023年连续入选“中国高被引学者(临床医学)”。

 

三、在研项目(仅限于主要负责人)

项目名称

来源

起止日期

泛血管疾病危险因素的防控系统

科技部国家重点研发计划

2021.12-2024.11

代谢性心血管疾病发病机制与干预研究

医院泛血管医学创新团队

2021/01-2025/12

纳米材料降低免疫反应用于 1 型糖尿病的研究

“科大新医学”联合基金

2021/01-2023/12

“千万量级”的基于真实世界数据的非设计化大数据方式的中国人群个体体检健康信息库

中国科学院战略性先导科技专项(B类)

2020.01-2024.12

四川眉山自然人群健康生命区间延长的生物标志物筛选及验证

国家自然科学基金专项项目

2020.01-2022.12

1型糖尿病易感HLA基因单倍型相关CD4+T细胞活化异常的调控机制

国家自然科学基金重点项目

2016.01-2020.12

1型糖尿病优化检测与治疗方案的研究及关键新技术推广

国家重点研发计划

2017.07-2020.12



四、主要研究方向(招生专业)及内容


主要招生方向:临床医学,生物学及数据科学

研究内容:

1、代谢(糖尿病)-泛血管病变临床与基础研究

2、糖尿病精准化诊疗

3、代谢性肝病临床与基础研究

4、大数据与智慧医疗

 

五、代表性论文(近五年)


[2022]

1. Wu X, Xu M, Liu Z, Zhang Z, Liu Y, Luo S, Zheng X, Little PJ, Xu S*, Weng J*. Pharmacological inhibition of IRAK1 and IRAK4 prevents endothelial inflammation and atherosclerosis in ApoE-/- mice. Pharmacol Res. 2022 Jan;175:106043.(JCR:Q1 中科院:二区,)

2. Luo S, Ran X, Zhang M, Hu J, Yang D, Zhu D, Zhao J, Xiao X, Guo X, Yang T, Huang Q, Liu F, Jing L, Ma J, Zhou X, Ping F, Gu N, Li W, Yang Y, Fang C, Bao W, Zheng X, Yan J, Zhou Z*, Weng J*. Pregnancy outcomes in women with type 1 diabetes in China during 2004 to 2014: A retrospective study (the CARNATION Study). J Diabetes. 2022 Jan;14(1):5-14.(JCR:Q2 中科院:二区)

3. Huang R, Zhou X, Chen G, Su L, Liu Z, Zhou P*, Weng J*, Min Y*. Advances of functional nanomaterials for magnetic resonance imaging and biomedical engineering applications. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2022 Apr 20:e1800.(JCR:Q1 中科院:二区)

4. Su M*, Zhao W*, Xu S*, Weng J*. Resveratrol in Treating Diabetes and Its Cardiovascular Complications: A Review of Its Mechanisms of Action. Antioxidants (Basel). 2022 May 30;11(6):1085.(JCR:Q1中科院:二区,IF=7.675)

5. Feng X, Xu S, Weng J*. Marijuana and endothelial dysfunction: new mechanism and therapy. Trends Mol Med. 2022 Jun 11:S1471-4914(22)00151-4. (JCR:Q1 中科院:一区,IF=15.272)


[2021]

6. Ling P, Yang D, Gu N, Xiao X, Lu J, Liu F, Zhou Z, Huang Q, Zhao J, Zhang M, Hu J, Luo S, Weng J*, Yan J*, Zheng X*. Achieving the HbA1c Target Requires Longer Time in Range in Pregnant Women With Type 1 Diabetes. J Clin Endocrinol Metab. 2021 Oct 21;106(11):e4309-e4317.(JCR:Q1 中科院:二区)

7. Ding Y, Zhou Y, Ling P, Feng X, Luo S, Zheng X, Little PJ, Xu S*, Weng J*. Metformin in cardiovascular diabetology: a focused review of its impact on endothelial function. Theranostics. 2021 Sep 9;11(19):9376-9396. (JCR:Q1 中科院:一区)

8. Ling P, Zheng X, Luo S, Ge J, Xu S*, Weng J*. Targeting angiopoietin-like 3 in atherosclerosis: From bench to bedside. Diabetes Obes Metab. 2021 Sep;23(9):2020-2034. (JCR:Q1中科院:二区)

9. Xu S, Ilyas I, Little PJ, Li H, Kamato D, Zheng X, Luo S, Li Z, Liu P, Han J, Harding IC, Ebong EE, Cameron SJ, Stewart AG, Weng J*. Endothelial Dysfunction in Atherosclerotic Cardiovascular Diseases and Beyond: From Mechanism to Pharmacotherapies. Pharmacol Rev. 2021 Jul;73(3):924-967. (JCR:Q1中科院:一区)

10. Xu S, Liu Y, Ding Y, Luo S, Zheng X, Wu X, Liu Z, Ilyas I, Chen S, Han S, Little PJ, Jain MK, Weng J*. The zinc finger transcription factor, KLF2, protects against COVID-19 associated endothelial dysfunction. Signal Transduct Target Ther. 2021 Jul 12;6(1):266.(JCR:Q1中科院:一区)

11. Feng X, Chen W, Ni X, Little PJ, Xu S*, Tang L*, Weng J*. Metformin, Macrophage Dysfunction and Atherosclerosis. Front Immunol. 2021 Jun 7;12:682853.(JCR:Q1中科院:二区)

12. Jiang Z, Ren W, Liang H, Yan J, Yang D, Luo S, Zheng X, Lin GW, Xian Y, Xu W, Yao B, Noble JA, Bei JX, Groop L, Weng J*. HLA class I genes modulate disease risk and age at onset together with DR-DQ in Chinese patients with insulin-requiring type 1 diabetes. Diabetologia. 2021 May 22.(JCR:Q1中科院:一区)

13. Weng J*, Zeng L, Zhang Y, Qu S, Wang X, Li P, Fu L, Ma B, Ye S, Sun J, Lu W, Liu Z, Chen D, Cheng Z, Liu H, Zhang T, Zou J. Henagliflozin as add-on therapy to metformin in patients with type 2 diabetes inadequately controlled with metformin: A multicentre, randomized, double-blind, placebo-controlled, phase 3 trial. Diabetes Obes Metab. 2021 Aug;23(8):1754-1764.(JCR:Q1中科院:二区)

14. Zheng X, Yang D, Luo S, Yan J, Guo X, Yang H, Bao W, Groop L, Dornhorst A,Weng J*; CARNATION Study Group. Association of Implementation of a Comprehensive Preconception-to-Pregnancy Management Plan With Pregnancy Outcomes Among Chinese Pregnant Women With Type 1 Diabetes: The CARNATION Study. Diabetes Care. 2021 Apr;44(4):883-892. (JCR:Q1中科院:一区)

15. Wu X, Luo S, Zheng X, Ding Y, Wang S, Ling P, Yue T, Xu W, Yan J, Weng J*. Glycemic control in children and teenagers with type 1 diabetes around lockdown for COVID-19: A continuous glucose monitoring-based observational study. J Diabetes Investig.2021 Feb 4:10.1111/jdi.13519. (JCR:Q3中科院:三区)

16. Weng J*, Zeng L, Zhang Y, Qu S, Wang X, Li P, Fu L, Ma B, Ye S, Sun J, Lu W,Liu Z, Chen D, Cheng Z, Liu H, Zhang T, Zou J. Henagliflozin as add-on therapy to metformin in patients with type 2 diabetes inadequately controlled with metformin: A multicentre, randomized, double-blind, placebo-controlled, phase 3 trial. Diabetes Obes Metab. 2021 Mar 26. (JCR:Q1中科院:二区)

17. Wang C, Luo S, Yang D, Yan J, Ding Y, Wang S, Ling P, Yao B, Zheng X*, Weng J*. Current practice and perspectives of healthcare providers regarding preconception care for women with type 1 diabetes in China. Diabetes Metab Res Rev. 2021 May;37(4):e3454. (JCR:Q1中科院:三区)

18. Ni L, Wen Z, Hu X, Tang W, Wang H, Zhou L, Wu L, Wang H, Xu C, Xu X, Xiao Z, Li Z, Li C, Liu Y, Duan J, Chen C, Li D, Zhang R, Li J, Yi Y, Huang W, Chen Y, Zhao J*, Zuo J, Weng J*, Jiang H*, Wang DW*. Effects of Shuanghuanglian oral liquids on patients with COVID-19: a randomized, open-label, parallel-controlled, multicenter clinical trial. Nature Public Health Emergency Collection. 2021 Oct;15(5):704-717. (JCR:Q1中科院:三区)

19. Liang H, Zhang Y, Li M, Yan J, Yang D, Luo S, Zheng X, Yang G, Li Z, Xu W, Groop L, Weng J*. Recognition of maturity-onset diabetes of the young in China. J Diabetes Investig. 2021 Apr;12(4):501-509. (JCR:Q3中科院:三区)

20. Wong CKH, Wan EYF, Luo S, Ding Y, Lau EHY, Ling P, Hu X, Lau ECH, Wong J, Zheng X*, Cowling BJ*, Weng J*, Leung GM*. Clinical outcomes of different therapeutic options for COVID-19 in two Chinese case cohorts: A propensity-score analysis. EClinicalMedicine. 2021 Feb;32:100743. (JCR:Q1)

21. Ren W, Yang D, Jiang Z, Xian Y, Huang Q, Luo S, Zheng X, Yan J, Xu W, Yao B,Wang CY, Bei JX, Groop L, Noble JA, Weng J*. Adult-onset type 1 diabetic patients with less severe clinical manifestation have less risk DR-DQ genotypes than childhood-onset patients. Diabetes Metab Res Rev. 2021 Jan;37(1):e3357. (JCR:Q1中科院:三区)


[2020]

22. Zhou Y, Deng H, Liu H, Yang D, Xu W, Yao B, Yan J*, Weng J*. Effects of novel flash glucose monitoring system on glycaemic control in adult patients with type 1 diabetes mellitus: protocol of a multicentre randomised controlled trial. BMJ Open. 2020 Dec 4;10(12):e039400. (JCR:Q2中科院:四区)

23. Zheng XY, Luo SH, Sun Y, Han MF, Liu J, Sun LY,Zhang LM,Ling P,Ding Y,Jin TC,Liu ZR,Weng JP*. Asymptomatic patients and asymptomatic phases of Coronavirus Disease 2019 (COVID-19): a population-based surveillance study. Natl Sci Rev.2020;7(10):1527-39. (JCR:Q1中科院:一区)

24. Yang D, Zhou Y, Luo S, Zheng X, Ling P, Qiu L, Xu W, Liang H, Yao B, Weng J*,Yan J*. Clinical Characteristics of Fulminant Type 1 Diabetes Compared with Typical Type 1 Diabetes: One-Year Follow-Up Study from the Guangdong T1DM Translational Medicine Study. J Diabetes Res. 2020 Feb 19;2020:8726268.(JCR:Q3中科院:三区)

25. Yang D, Yan J, Deng H, Yang X, Luo S, Zheng X, Lv J, Liang W, Hong M, Wu Z, Yao B, Weng J*, Xu W*. Effects of Metformin Added to Insulin in Adolescents with Type 1 Diabetes: An Exploratory Crossover Randomized Trial. J Diabetes Res. 2020 Dec 24;2020:7419345. (JCR:Q3中科院:三区)

26. Xu F, Cao H, Chen Z, Gu H, Guo W, Lin B, Weng J*. Short-term GLP-1 receptor agonist exenatide ameliorates intramyocellular lipid deposition without weight loss in ob/ob mice. Int J Obes (Lond). 2020 Apr;44(4):937-947. (JCR:Q3中科院:二区,IF=4.061)

27. Xian Y, Xu H, Gao Y, Yan J, Lv J, Ren W, Huang Q, Jiang Z, Xu F, Yao B, Weng J*. A pilot study of preproinsulin peptides reactivity in Chinese patients with type 1 diabetes. Diabetes Metab Res Rev. 2020 Feb;36(2):e3228.(JCR:Q1中科院:三区)

28. Wu Z, Luo S, Zheng X, Bi Y, Xu W, Yan J, Yang D, Weng J*. Use of a do-it- yourself artificial pancreas system is associated with better glucose management and higher quality of life among adults with type 1 diabetes. Ther Adv Endocrinol Metab. 2020 Aug 25;11:2042018820950146. (JCR:Q2中科院:四区)

29. Weng J*, Zhao J, Zhou Z, Guo X, Zou D, Ji Q, Tong N, Li Q, Zhu J, Li Q, Qin G, Feng P, Yang L, Gao Z, Chen L, Li H, Li Y, Zeng L, Zhu D, Lu J, Luo T, Cui N. Observational study evaluating the effectiveness of physician-targeted education for improving glycemic management of patients with type 2 diabetes (BEYOND II). J Diabetes. 2020 Jan;12(1):66-76. (JCR:Q2中科院:二区)

30. Pan W, Zheng X, Chen G, Su L, Luo S, Wang W, Ye S, Weng J*, Min Y*. Nanotechnology's application in Type 1 diabetes. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2020 Nov;12(6):e1645. (JCR:Q1中科院:二区)

31. Luo SH, Liu W, Liu ZJ, Zheng XY, Hong CX, Liu ZR, Liu J, Weng JP*. A confirmed asymptomatic carrier of 2019 novel coronavirus. Chin Med J (Engl). 2020 May 5;133(9):1123-1125. (JCR:Q1中科院:三区)

32. Liu X, Wang L, Xing Y, Engel SS, Zeng L, Yao B, Xu W, Chen G, Zhang Y, Zhang R, Liu S, Weng J*, Ji Q*. Efficacy and safety of metformin and sitagliptin-based dual and triple therapy in elderly Chinese patients with type 2 diabetes: Subgroup analysis of STRATEGY study. J Diabetes Investig. 2020 Nov;11(6):1532-1541.(JCR:Q3中科院:三区)

33. Liu H, Yang D, Deng H, Xu W, Lv J, Zhou Y, Luo S, Zheng X, Liang H, Yao B, Qiu L, Wang F, Liu F, Yan J*, Weng J*. Impacts of glycemic variability on the relationship between glucose management indicator from iPro(™)2 and laboratory hemoglobin A1c in adult patients with type 1 diabetes mellitus. Ther Adv Endocrinol Metab. 2020 Jun 8;11:2042018820931664. (JCR:Q2中科院:四区)

34. Qiu L, Ling P, Yang D, Luo S, Zheng X, Liang H, Yuan Y, Liang G, Xu W, Yao B, Yan J*, Weng J. Current status of metformin in addition to insulin therapy in adult patients with type 1 diabetes mellitus: An analysis from the Guangdong Type 1 Diabetes Mellitus Translational Medicine Study. J Diabetes. 2020 Oct;12(10):754-760. (JCR:Q2中科院:二区)


[2019]

35. Ding Y, Luo S, Zheng X, Ling P, Yue T, Liu Z, Weng J*. Association between population migration and epidemic control of Coronavirus disease 2019. Sci China Life Sci. 2020 Jun;63(6):936-939. (JCR:Q1中科院:一区)

36. Zhu M, Xu K, Chen Y, Gu Y, Zhang M, Luo F, Liu Y, Gu W, Hu J, Xu H, Xie Z, Sun C, Li Y, Sun M, Xu X, Hsu HT, Chen H, Fu Q, Shi Y, Xu J, Ji L, Liu J, Bian L, Zhu J, Chen S, Xiao L, Li X, Jiang H, Shen M, Huang Q, Fang C, Li X, Huang G, Fan J, Jiang Z, Jiang Y, Dai J, Ma H, Zheng S, Cai Y, Dai H, Zheng X, Zhou H, Ni S, Jin G, She JX, Yu L, Polychronakos C, Hu Z*, Zhou Z*, Weng J*, Shen H*, Yang T*. Identification of Novel T1D Risk Loci and Their Association With Age and Islet Function at Diagnosis in Autoantibody-Positive T1D Individuals: Based on a Two- Stage Genome-Wide Association Study. Diabetes Care. 2019 Aug;42(8):1414-1421.(JCR:Q1中科院:一区)

37. Yang X, Xu W, Zhu Y, Deng H, Tan Y, Zeng L, Weng J*. Decreased β-Cell Function is Associated with Cardiovascular Autonomic Neuropathy in Chinese Patients Newly Diagnosed with Type 2 Diabetes. Neurosci Bull. 2019 Feb;35(1):25-33. (JCR:Q2中科院:二区)

38. Yang X, Deng H, Zhang X, Yang D, Yan J, Yao B, Weng J*, Xu W*. Insulin requirement profiles and related factors of insulin pump therapy in patients with type 2 diabetes. Sci China Life Sci. 2019 Nov;62(11):1506-1513.(JCR:Q1中科院:一区)

39. Yan J, Yao B, Kuang H, Yang X, Huang Q, Hong T, Li Y, Dou J, Yang W, Qin G, Yuan H, Xiao X, Luo S, Shan Z, Deng H, Tan Y, Xu F, Xu W, Zeng L, Kang Z, Weng J*. Liraglutide, Sitagliptin, and Insulin Glargine Added to Metformin: The Effect on Body Weight and Intrahepatic Lipid in Patients With Type 2 Diabetes Mellitus and Nonalcoholic Fatty Liver Disease. Hepatology. 2019 Jun;69(6):2414-2426.(JCR:Q1中科院:一区)

40. Xian Y, Chen Z, Deng H, Cai M, Liang H, Xu W, Weng J*, Xu F*. Exenatide mitigates inflammation and hypoxia along with improved angiogenesis in obese fat tissue. J Endocrinol. 2019 Aug;242(2):79-89. (JCR:Q2中科院:三区)

41. Wu Z, Jin T, Weng J*. A thorough analysis of diabetes research in China from 1995 to 2015: current scenario and future scope. Sci China Life Sci. 2019 Jan;62(1):46-62. (JCR:Q1中科院:一区)

42. Pan W, Zhang K, Li H, Wu M, Weng J*. Older adults are prioritized in terms of waiting time under the emergency triage system in Guangzhou, China. Geriatr Gerontol Int. 2019 Aug;19(8):786-791. (JCR:Q2中科院:三区)

43. Li X, Xu Z, Ji L, Guo L, Liu J, Feng K, Xu Y, Zhu D, Jia W, Ran X, Chen L,Zhao S, Shi B, Zhu J, Shan Z, Zhou Z, Zeng L, Weng J*; cooperative group on Direct Medical Cost Investigation of Diabetes in Chinese Urban Tertiary Hospitals, Chinese Diabetes Society. Direct medical costs for patients with type 2 diabetes in 16 tertiary hospitals in urban China: A multicenter prospective cohort study. J Diabetes Investig. 2019 Mar;10(2):539-551. (JCR:Q3中科院:三区)

44. Jia W*, Weng J*, Zhu D, Ji L, Lu J, Zhou Z, Zou D, Guo L, Ji Q, Chen L, Chen L, Dou J, Guo X, Kuang H, Li L, Li Q, Li X, Liu J, Ran X, Shi L, Song G, Xiao X,Yang L, Zhao Z; Chinese Diabetes Society. Standards of medical care for type 2 diabetes in China 2019. Diabetes Metab Res Rev. 2019 Sep;35(6):e3158. (JCR:Q1中科院:三区)


[2018]

45. Weng J*, Zhou Z, Guo L, Zhu D, Ji L, Luo X, Mu Y, Jia W; T1D China Study Group. Incidence of type 1 diabetes in China, 2010-13: population based study. BMJ. 2018 Jan 3;360:j5295. (JCR:Q1中科院:一区)

46. Liu L, Yan J, Xu H, Zhu Y, Liang H, Pan W, Yao B, Han X, Ye J, Weng J*. Two Novel MicroRNA Biomarkers Related to β-Cell Damage and Their Potential Values for Early Diagnosis of Type 1 Diabetes. J Clin Endocrinol Metab. 2018 Apr 1;103(4):1320-1329. (JCR:Q1中科院:二区)



六、联系方式


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